Recruiting

COsegregation of VARiants in Panel of Genes

The aim of the COVAR project is to achieve reliable classification of as many variants of interest as possible from the French OncoGenetics Database (FrOG, https://frog-db.fr/) in order to use them for the genetic counseling. The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some cases to propose a prophylactic surgery.

ClinicalTrials.gov IDNCT01689584

PhaseNA

Enrollment11000

SponsorInstitut Curie

Age18 Years

SexALL

I'm interested View official listing

Conditions studied

Gene Mutation-Related Cancer, Genetic Predisposition

About this study

Interventions

Genetic: salivary kit — The saliva samples will be made of selected related (DNA).

Primary outcomes

Perform the co-segregation analysis of the selected VUS (class 3) or likely pathogenic variant (class 4) in the families. (up to 15 years)

Eligibility information

Inclusion Criteria: Index cases: * A person carrying a variant of interest in a gene analyzed in a diagnostic setting by one of the laboratories within the Genetics and Cancer Group (GGC)-Unicancer network, classified as class 3, 4 or hypomorphic class 5, and selected by the national expert group for the gene concerned. * Age ≥ 18 years. * Signed written inform consent "index case" Related parties: * Any relative of an index case with cancer * Any relative without cancer related to an index case, selected by the investigators, according to family structure and degree of related compared to the index case * For class 4 and hypomorphic class 5 variants; relatives currently undergoing analysis or having already obtained a test result for the variant of interest as part of clinical care. * Age ≥ 18 years * Information and signature of the informed consent "selected relatives" Exclusion Criteria: * Minors * Persons deprived of liberty or under guardianship (including curators). * Absence of signed written inform consent

Study locations

Centre Hospitalier de Bastia, Bastia, Corsica 20604 France
Institut Curie - Saint-Cloud site, Saint-Cloud, Haut de Seine 92210 France
CHU Amiens - Hôpital Nord, Amiens, 80054 France
ICO - Centre Paul Papin, Angers, 49933 France
Centre Hospitalier d'Angoulème, Angoulême, 16959 France
Institut Sainte-Catherine, Avignon, 84918 France
CHU Besançon, Besançon, 25030 France
Groupe Hospitalier Pellegrin, Bordeaux, 33076 France
Institut Bergonié, Bordeaux, 33076 France
Centre Hospitalier Jacques Coeur, Bourges, 18020 France

Showing 10 of 62 reported sites. See the official listing for all locations.

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-29.