Recruiting
Cirrhosis, Effects of TRAnsplantation and Diabetes
This observational study is aimed at assessing insulin secretion and sensitivity by the use of a mathematical modeling from oral glucose tolerance test in subjects with liver cirrhosis undergoing orthotopic liver transplantation (OLT), before and at various time points after OLT.
ClinicalTrials.gov IDNCT02038517
PhaseNot Applicable
Enrollment200
SponsorFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Age18 Years
SexALL
Conditions studied
Liver Cirrhosis
About this study
This observational study is aimed at assessing insulin secretion and sensitivity by the use of a mathematical modeling from oral glucose tolerance test in subjects with liver cirrhosis undergoing orthotopic liver transplantation (OLT), before and at various time points after OLT.
Primary outcomes
- Relationship of insulin secretion and sensitivity with the development of abnormalities of glucose metabolism after OLT (10 years)
Eligibility information
Inclusion Criteria:
Subjects with end-stage liver cirrhosis in waiting list for orthotopic liver transplantation at the Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico, Milan, Italy
Exclusion Criteria:
* Known diabetes
* Cystic fibrosis
* Pregnancy
Study locations
- Endocrinology and Diabetes Unit, Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico, Milan, MI 20122 Italy
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.