Recruiting
Triple Negative Breast Cancer and Germline Hereditary Breast and Ovarian Cancer Mutation Carrier Registry
PROGECT is a registry for patients with Triple Negative breast cancer (TNBC) or patients who have an identified germline mutations (such as a mutation on the BRCA1 or BRCA2 genes).
ClinicalTrials.gov IDNCT02302742
PhaseNot Applicable
Enrollment3000
SponsorUniversity of Kansas Medical Center
AgeNo minimum reported
SexALL
Conditions studied
Breast Cancer, Hereditary Breast and Ovarian Cancer
About this study
PROGECT is a registry for patients with Triple Negative breast cancer (TNBC) or patients who have an identified germline mutations (such as a mutation on the BRCA1 or BRCA2 genes).
Primary outcomes
- Prevalence of germline mutations (such as BRCA1/2 mutations) in patients with TNBC (5 years)
- . Predictors of response to neo/adjuvant chemotherapy in patients with TNBC (5 years)
- Long term Disease free and overall survival rates in TNBC patients treated with different systemic therapies (10 years)
Eligibility information
Inclusion criteria include:
Triple Negative Breast Cancer
* ER/PR \<10% and HER negative per current ASCO/CAP guidelines
* Stages I-IV
* Any age at diagnosis
* Patient must be within 5 years of diagnosis
* Eligible regardless of genetic testing status
* Genetic testing recommended for patients meeting NCCN and Medicare guidelines
AND/OR
Germline mutation Carriers
* Patients with deleterious or uncertain mutations in HBOC genes (BRCA, PTEN, P53, -PALB2 etc) are eligible regardless of type/site of cancer
* Healthy patients harboring mutations also eligible
* There is no time limit from the time of diagnosis of cancer and enrollment.
* Eligible regardless of personal history of cancer
Exclusion Criteria include:
Triple Negative Breast Cancer -Patient is not within five years of diagnosis
Germline mutation Carriers:
-Patient only carries a HBOC mutation that is classified as "polymorphism" of "favor polymorphism"
Study locations
- Hays Medical Center Dreiling-Schmidt Cancer Institute, Hays, Kansas 67601 United States
- KCCC West, Kansas City, Kansas 66112 United States
- KCCC Overland Park, Overland Park, Kansas 66210 United States
- Overland Park Regional Medical Center, Overland Park, Kansas 66215 United States
- Salina Regional Health Center - Tammy Walker Cancer Center, Salina, Kansas 67401 United States
- The University of Kansas Cancer Center, Westwood, Kansas 66205 United States
- Universtiy Health, Kansas City, Missouri 64108 United States
- KCCC South, Kansas City, Missouri 64131 United States
- Research Medical Center, Kansas City, Missouri 64132 United States
- KCCC - North, Kansas City, Missouri 64154 United States
Showing 10 of 11 reported sites. See the official listing for all locations.
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.