Clinical trials / NCT02496468
Recruiting

Pediatric Arm of DZL All Age Asthma Cohort

Despite its common occurrence, still little is known about pathomechanisms determining different wheeze and asthma trajectories and phenotypes in children, and those beginning in adulthood. Therefore, deciphering underlying determinants for different childhood and adult asthma phenotypes is urgently needed to develop personalized treatment approaches targeting distinct underlying mechanisms. Thereby, secondary prevention early in the disease process can also be achieved. The decoding of such mechanisms and their…

ClinicalTrials.gov IDNCT02496468
PhaseNot Applicable
Enrollment1500
SponsorLMU Klinikum
Age6 Months
SexALL
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Conditions studied

Asthma, Wheeze, Hypersensitivity, Endophenotype

About this study

Despite its common occurrence, still little is known about pathomechanisms determining different wheeze and asthma trajectories and phenotypes in children, and those beginning in adulthood. Therefore, deciphering underlying determinants for different childhood and adult asthma phenotypes is urgently needed to develop personalized treatment approaches targeting distinct underlying mechanisms. Thereby, secondary prevention early in the disease process can also be achieved. The decoding of such mechanisms and their translation to the individual patient is the aim of the Disease Area Asthma Allergy of the 'German Centre for Lung Research' (DZL).

Primary outcomes

Eligibility information

Inclusion Criteria: * informed consent by parents (and by children if age \> 8 years) * age 6 months to 18 years * term delivery (≥ 37 weeks) * active/passive understanding of German * age 6 months - \< 6 years: preschool wheeze (more than two episodes of wheeze during 12 months prior to inclusion) * age at least 6 years: doctor diagnosed asthma (according to current guidelines) Exclusion Criteria: * known inborn or perinatal pulmonary disease * airway malformation * oxygen therapy after birth with a duration of more than 24 hours * ventilator support or mechanical ventilation after birth * diagnoses of cystic fibrosis; primary ciliary dyskinesia * heart failure diagnosed after birth affecting pulmonary circulation * major respiratory diseases such as e.g. interstitial lung disease * any current non-atopic comorbidity * fever of at least 38.5°C during the last two weeks prior to the planned first visit

Study locations

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.