Recruiting

Swiss Paediatric Airway Cohort

ClinicalTrials.gov IDNCT03505216

PhaseNot Applicable

Enrollment6000

SponsorUniversity of Bern

Age0 Years

SexALL

I'm interested View official listing

Conditions studied

Asthma, Wheezing, Cough, Exercise Induced Bronchospasm, Inspiratory Laryngeal Obstruction, Dysfunctional Breathing

About this study

The Swiss Paediatric Airway Cohort (SPAC) is a national, prospective clinical cohort of children and adolescents who visit physicians in Switzerland for recurrent wheeze, cough, and exercise- or sleep-related respiratory problems. SPAC aims to answer important questions on clinical phenotypes, prognosis, diagnosis and treatment. SPAC is part of routine care, and only clinically indicated investigations are done. The comprehensive baseline assessment includes a detailed questionnaire to families, plus test results, diagnoses and treatments from hospital records. Follow-up is via monthly questionnaires the first 12 months and thereafter annual questionnaires to families, and data from follow-up visits. Currently, 4344 patients from 10 clinics and hospitals in Switzerland (Aarau, Basel, Bern, Chur, Horgen, Lausanne, Luzern, St. Gallen, Worb, Zurich) have been enrolled. SPAC provides real-life data on children visiting the Swiss health care system for common respiratory problems. It will provide a research platform for health services research, and for nested clinical and transitional studies. Publications and plain language summaries are listed on the study website: https://www.spac-study.ch/publikationen/

Primary outcomes

Wheeze (1 year from inclusion in SPAC study)
Cough apart from colds (1 year from inclusion in SPAC study)
Exercise-induced dyspnea (1 year from inclusion in SPAC study)
Reduced lung function (1 year from inclusion in SPAC study)

Eligibility information

Inclusion Criteria: * Children and adolescents aged 0-16 years * Resident in Switzerland * Seen in a paediatric pulmonary outpatient clinic due to respiratory problems * Parents and patients above age 14 must be able to sign an informed consent form Exclusion Criteria: Prior diagnosis of cystic fibrosis, primary ciliary dyskinesia, severe heart disease, oncological disease, neuromuscular disease or severe disability

Study locations

Vienna Open Medical Institute, Vienna, Austria
Children's hospital Aarau, Aarau, Switzerland
University Children's hospital Basel, UKBB, Basel, Switzerland
Institute of Social and Preventive Medicine, Bern, 3012 Switzerland
University Children's Hospital Bern, Inselspital, Bern, Switzerland
Children's Hospital Chur, Chur, Switzerland
Pulmonology clinic, Horgen, Horgen, Switzerland
University Children's hospital Lausane, CHUV, Lausanne, Switzerland
Children's hospital Lucerne, Lucerne, Switzerland
Children's hospital St. Gallen, Sankt Gallen, Switzerland

Showing 10 of 12 reported sites. See the official listing for all locations.

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.