Recruiting

Nanshan Elderly Cohort Study

ClinicalTrials.gov IDNCT03569735

PhaseNot Applicable

Enrollment20000

SponsorSun Yat-sen University

Age65 Years

SexALL

I'm interested View official listing

Conditions studied

Hypertension, Type 2 Diabetes Mellitus, Cardiovascular Diseases, Stroke, Obesity, Metabolic Syndrome, Sarcopenia, Chronic Kidney Disease, Cancer, Death

About this study

Objective: The Nanshan Elderly Cohort Study (NECS) aims to investigate the nutritional, as well as other environmental and genetic factors of chronic diseases, such as cardio-metabolic diseases. Study design: NECS is a community-based prospective cohort study. Participants: About 10000-20000 apparently healthy residents, living in Nanshan， Shenzhen (South China) for \>5 years, aged ≥ 65 years, will be recruited between 2018 and 2019. Visits and Data Collection: Participants will be followed up approximately every 3 years by invited to the Community Healthcare Service Centre. At each survey, face-to-face interviews, anthropometric measurements, ultrasonography examination, electrocardiogram test and specimen collection will be conducted. Key variables: 1. Face-to-face interviews: Structured questionnaires will be used to collect the participants' socio-demographic characteristics, lifestyles, habitual dietary intake, physical activity, history of chronic diseases, use of supplements and medications, family history, psychological health and cognitive function. 2. Physical examinations: Anthropometric measurements, blood pressure tests, handgrip strength, and usual gait speed. 3. Ultrasonography examinations: Ultrasonography examination will be performed to determine carotid artery intima-media thickness and plaque, fatty liver. 4. Electrocardiogram test: Electrocardiogram test is to obtain information about the structure and function of the heart. 5. Specimen collections: Overnight fasting blood sample, early morning first-void urine sample and faeces samples will be collected and stored at -80°C till tests. 6. Laboratory tests: 1. Blood tests: Metabolic syndrome-related indices; nutritional indices; inflammatory markers; sexual hormones; genetic markers. 2. Urinary tests: Flavonoids and flavones, minerals, creatinine and renal function related markers. 3. Fecal test: Gut microbiota and related metabolites. 7. Morbidity and mortality: Relevant data will be also retrieved via local multiple Health information systems. 8. Others: Many other laboratory tests or instrument tests will be developed depended on needs and resources in future.

Primary outcomes

Diabetes mellitus (Up to 10 years)
Cardiovascular diseases (occurrence of cardiovascular diseases) (Up to 10 years)
Stroke (occurrence of stroke) (Up to 10 years)
Cognitive disorder (occurrence of cognitive disorder) (Up to 10 years)

Eligibility information

Inclusion Criteria: * Age: ≥ 65 years; * Living in Nanshan, Shenzhen for at least 5 years; * Chinese. Exclusion Criteria: * Had a history of hospital-confirmed diabetes, failure(s) of heart, liver, or kidney, cancer, CVD events; * On special diet due to a disease or weight control; * Mental and physical disability; * Likely to move to other city within 5 years; * Did not want to attend any one item of the survey or sample collection.

Study locations

Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054 China
Department of Medical Statistics & Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080 China

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.