Recruiting

Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention

The study is aimed * To quantify the change of adipose tissues, triglyceride in liver and pancreas and cholesterol after lifestyle intervention or bariatric surgery. * To test the hypothesis that Brown fat is an independent biomarker for the development of Non Alcoholic Fat Liver Disease (NAFLD) * To study the association among Brown fat, NAFLD and obesity.

ClinicalTrials.gov IDNCT03875625

PhaseNA

Enrollment80

SponsorChinese University of Hong Kong

Age18 Years

SexALL

I'm interested View official listing

Conditions studied

Non-Alcoholic Fatty Liver Disease, Obesity, Morbid, Brown Fat, Metabolic Disease, Diabetes Mellitus, Insulin Resistance, Abdominal Subcutaneous Fat

About this study

Interventions

Procedure: Bariatric surgery — Use of the normal bariatric surgery procedures commonly conducted in our hospital, such as: Laparoscopic Roux-en-Y gastric bypass (RYGB) and Laparoscopic sleeve gastrectomy (LSG)
Behavioral: Dietitian led life style modification intervention — Intensive 6 months life style changes supervised by diatitians.
Behavioral: Conventional care (control) — receive routine care

Primary outcomes

Use of modified Dixon Magnetic Resonance Imaging method to measure the response of adipose tissue in different organs following life style modification program or Bariatric surgery (one year)
Use of modified Dixon Magnetic Resonance Imaging method to measure the response of adipose tissue in different organs following life style modification program or Bariatric surgery 2 (one year)
Use of modified Dixon Magnetic Resonance Imaging method to measure the response of adipose tissue in different organs following life style modification program or Bariatric surgery- 3 (one year)
Use of modified Dixon Magnetic Resonance Imaging method to measure the response of adipose tissue in different organs following life style modification program or Bariatric surgery- 4 (one year)
Use of modified Dixon Magnetic Resonance Imaging method to assess the relationship between Brown Adipose Tissue and Non Alcoholic Fatty Liver Disease (one year)
Blood biochemistry for assessing β-cell function and insulin resistance (IR) (one year)
Blood biochemistry- 1 (one year)
Blood biochemistry- 2 (one year)

Eligibility information

Inclusion Criteria: * BMI ≥ 25-30 kg/m2 * BMI ≥ 30 kg/m2 with Metabolic syndrome * BMI ≥ 35 kg/m2 for morbid obesity Exclusion Criteria: * Other kind of hepatic diseases * Under medications known to affect liver fat * Waist circumference ≥ 150 cm * Weight ≥ 250 kg * MRI contraindications

Study locations

The Chinese University of Hong Kong, Prince of Wale Hospital, Hong Kong, Shatin Hong Kong

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.