Recruiting
Phenotyping Genetic Risk for Type 2 Diabetes
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.
ClinicalTrials.gov IDNCT04024631
PhaseNA
Enrollment100
SponsorUniversity of Pennsylvania
Age10 Years
SexALL
Conditions studied
Diabetes Mellitus, Type 2, Genetics
About this study
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.
Interventions
- Other: 75g glucose beverage (Glucola, Trutol, or similar brand) — Subjects will present fasting to the study day and ingest the glucose beverage during the oral glucose tolerance test.
- Other: DXA, whole body — Subjects will undergo a whole body DXA scan for assessment of adiposity index and body fat distribution.
Primary outcomes
- Glucose response to an oral glucose load (samples will be collected over four hours and these results will be used to calculate area under the curve)
Eligibility information
Inclusion Criteria:
* Age 10-70 years
* Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research.
* Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher
Exclusion Criteria:
* prior diagnosis of type 1, type 2, or secondary diabetes
* use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication
* acute illness that may impact insulin and glucose dynamics
* pregnancy
* hypothalamic obesity or related genetic disorder of metabolism
* recent systemic chemotherapy use
* gastrointestinal impairment or surgery that may impact absorption
* anemia
* major organ system illness or any underlying condition requiring regular medication or treatment that could make implementation of the protocol or interpretation of the study results difficult
* inability to comply with study protocol
Study locations
- Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 United States
- University of Pennsylvania, Philadelphia, Pennsylvania 19104 United States
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.