Recruiting

Glucose Variability and Cognition in Prediabetes

This study examines the association of variability in glucose values over a 10-day period with cognitive function and functional status among individuals with prediabetes, aged 50 or older.

ClinicalTrials.gov IDNCT04201600

PhaseNot Applicable

Enrollment30

SponsorUniversity of Maryland, Baltimore

Age50 Years

SexALL

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Conditions studied

Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline, Functional Status, PreDiabetes, Aging, Depression

About this study

This study examines the association of variability in glucose values over a 10-day period with cognitive function and functional status among individuals with prediabetes, aged 50 or older.

Interventions

Device: Continuous Glucose Monitoring System (CGMS) — Continuous Glucose Monitoring System (CGMS)- minimally invasive sensors that measure glucose concentrations at 5-min intervals over several days.

Primary outcomes

Aggregate Executive Functioning Score (Day 10)
Aggregate Memory Score (Day 10)
Aggregate Language Score (Day 10)

Eligibility information

Inclusion Criteria: * Aged 50 years and older * At least 8th grade education Exclusion Criteria: * Diagnosed type 1 or type 2 diabetes * Current use of mediation for diabetes (oral hypoglycemic agents, insulin), or with diabetic properties (e.g., steroids) * Chronic disorders (cardiovascular disease, peripheral vascular disease, stroke, transient ischemic attack, chronic kidney disease, past year cancer) * Neurological disorders (e.g., Parkinson's, epilepsy, multiple sclerosis) * History of dementia or suspected dementia * Known HIV * Serious mental illness, psychosis, or use of psychotropic medication * Heavy alcohol use

Study locations

Baltimore VA Geriatric Research Education and Clinical Center (GRECC), Baltimore, Maryland 21201 United States

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.