Dissecting Host-microbiome Modifiers of Type 2 Diabetes Risk
It is now well documented that changes in gut microbiota composition accompany obesity and type 2 diabetes (T2D) and contribute to low-grade inflammation, insulin resistance,and glucose intolerance. It is not yet clear if T2D predisposes the intestine to allow more microbial products or possibly live bacteria to subvert the gut mucosal barrier. However, it is known that hyperglycemia during T2D induces a more permissive gut barrier allowing increased penetration of microbes and their products into the blood. An…
Conditions studied
Type 2 Diabetes
About this study
It is now well documented that changes in gut microbiota composition accompany obesity and type 2 diabetes (T2D) and contribute to low-grade inflammation, insulin resistance,and glucose intolerance. It is not yet clear if T2D predisposes the intestine to allow more microbial products or possibly live bacteria to subvert the gut mucosal barrier. However, it is known that hyperglycemia during T2D induces a more permissive gut barrier allowing increased penetration of microbes and their products into the blood. An important next step is to determine which strains of bacteria promote dysbiosis, allowing bacteria or bacterial components to subvert the gut barrier and alter glucose control. It is hypothesized that gut microbes in the colon and other lower gut segments are key modulators of energy balance, glucose homeostasis and insulin sensitivity.
Interventions
- Procedure: Endoscopy and duodenal biopsy and sampling — All volunteers will have endoscopy and duodenal biopsy and will have to provide stool samples
Primary outcomes
- Microbial signature (One week)
Eligibility information
Study locations
- INAF, Université Laval, Québec, Quebec G1V 0A6 Canada
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-22.