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Long-term of Remote Ischemic Preconditioning and Mindfulness in Patients With Mild Hypertension

ClinicalTrials.gov IDNCT04753840

PhaseNA

Enrollment400

SponsorHenan Institute of Cardiovascular Epidemiology

Age18 Years

SexALL

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Conditions studied

Hypertension

About this study

According to the latest survey data of China hypertension annual meeting, there are about 300 million patients with hypertension in China, with 10 million new cases of hypertension each year, and there is an obvious trend of younger people. In particular, young and middle-aged people are in a state of mild hypertension for a long time, which causes great pressure on health and medical treatment. At present, the main clinical measures for mild hypertension are to change their eating habits, quit smoking and alcohol, exercise and other lifestyle changes, as well as drug control. For most patients with mild hypertension, drug control is not the best choice. It has been reported that remote ischemic preconditioning (RIPC) may play an effective role in reducing blood pressure .The purpose of this study was to investigate the extent of long-term application of RIPC to reduce blood pressure in patients with mild hypertension.

Interventions

Device: CRIC — Remote Ischemic Conditioning (CRIC): Twice daily for 12 weeks using an automated cuff device. Each 30-minute session consisted of 3 cycles of 6 min inflation (pressure individualized: resting SBP-based increments of +40/+30/+20 mmHg depending on baseline SBP level) followed by 4 min deflation (0 mmHg).
Behavioral: MFT — Sham CRIC: Identical schedule and device; each cycle used fixed 5 min inflation at 60 mmHg (non-ischemic) followed by 5 min deflation.
Other: sham CRIC — Sham CRIC: Identical schedule and device; each cycle used fixed 5 min inflation at 60 mmHg (non-ischemic) followed by 5 min deflation.
Other: sham MFT — Sham MFT: Twice daily equivalent-duration audio of looped neutral nature sounds (ocean waves, flowing water, birdsong) without mindfulness instructions.

Primary outcomes

Mean systolic blood pressure (3 months)
Mean diastolic blood pressure (3 months)

Eligibility information

Inclusion Criteria: * Diagnosed patients with mild hypertension (SBP: 140\~159mmHg; DBP: 90\~99mmHg) Exclusion Criteria: * Cannot tolerate RIPC * Non-essential hypertension * patients who have uncontrolled severe arrhythmia, diabetes, electrolyte disturbance * patients who have severe organic diseases such acute myocardial infarction, cardiac insufficiency, abnormal renal function, etc.

Study locations

Fuwai central China Cardiovascular hospital, Zhengzhou, Henan 450008 China

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.