Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes
The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.
Conditions studied
Type 2 Diabetes, Overweight and Obesity
About this study
The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.
Interventions
- Behavioral: Cardiovascular exercise — 15 weeks of cardiovascular exercise 3x/week for 50 minutes/session
Primary outcomes
- Change in peak oxygen consumption (VO2) (Through study completion, approximately 4 months)
- Change in insulin sensitivity (Through study completion, approximately 4 months)
Eligibility information
Study locations
- University of Colorado, Aurora, Colorado 80045 United States
- University of Virginia, Charlottesville, Virginia 22908 United States
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.