Recruiting
Cognitive Training and Brain Stimulation in Women With Post-chemotherapy Cognitive Impairment
The aim of this study is to investigate whether a high definition tDCS-accompanied intensive cognitive training of working memory leads to performance improvement in women with post-chemotherapy cognitive impairment after breast cancer treatment.
ClinicalTrials.gov IDNCT04817566
PhaseNA
Enrollment52
SponsorUniversity Medicine Greifswald
Age18 Years
SexFEMALE
Conditions studied
Breast Cancer, Cognitive Impairment
About this study
The aim of this study is to investigate whether a high definition tDCS-accompanied intensive cognitive training of working memory leads to performance improvement in women with post-chemotherapy cognitive impairment after breast cancer treatment.
Interventions
- Device: Anodal tDCS — Anodal transcranial direct current stimulation (tDCS), 9 sessions with 20 minutes stimulation each (2 mA).
- Device: Sham tDCS — Sham transcranial direct current stimulation (tDCS), 9 sessions with 30 sec stimulation each (2 mA) to ensure blinding of participants.
- Behavioral: Intensive cognitive training — Intensive cognitive training of a letter memory updating task, 9 sessions for approximately 20 min
Primary outcomes
- Working memory performance at post-assessment (3 weeks)
Eligibility information
Inclusion Criteria:
1. Chemotherapy to treat breast cancer (≥ 6 months post-treatment).
2. Self-reported concerns regarding cognitive functioning.
3. Age: 18-65 years.
4. right-handedness
Exclusion Criteria:
1. History of dementia before treatment of cancer.
2. Other neurodegenerative neurological disorders; epilepsy or history of seizures.
3. Severe and untreated medical conditions that preclude participation in the training, as determined by responsible physician.
4. History of moderate to severe substance use disorder according to DSM-5
5. Moderate to severe acute psychiatric disorders according to DSM-5
6. Contraindication to tDCS application (Antal et al., 2017)
Study locations
- University Medicine Greifswald, Greifswald, Germany
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-03.