Transdiagnostic Cognitive Biomarkers
The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as…
Conditions studied
Pain, Depression
About this study
The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls.
Interventions
- Behavioral: Computer game/task — N-back, COGED, PacMan game, Bandit task, Websurf task.
- Behavioral: Health surveys online — Health surveys to study themes like pain, sleep, depression and anxiety, and PTSD.
Primary outcomes
- Feasibility for all aspects of the study (1-7 days)
Eligibility information
Study locations
- University of Minnesota, Minneapolis, Minnesota 55455 United States
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.