Recruiting

Effects of an Evening PROtein PrEload on Metabolic Health in Night ShIfT Workers (PROPENSITy)

This study will compare the effects of a whey protein supplement or a placebo consumed before the evening meal on health outcomes in night shift workers.

ClinicalTrials.gov IDNCT04869098
PhaseNA
Enrollment30
SponsorUniversity of Adelaide
Age35 Years
SexFEMALE
I'm interested View official listing

Conditions studied

Type 2 Diabetes, Shift-work Disorder

About this study

This study will compare the effects of a whey protein supplement or a placebo consumed before the evening meal on health outcomes in night shift workers.

Interventions

Primary outcomes

Eligibility information

Inclusion Criteria: * Female * Night shift workers (with a minimum of 6 months in their current shift work schedule) * 35-65 years * BMI 28.0-35.0 kg/m2; waist circumference \> 80cm * Weight stable in the past 6 months Exclusion Criteria: * Those working standard day time hours only, or those who work less than three to four night shifts per fortnight on average * Personal history and/or diagnosis of: diabetes, cancer, major psychiatric disorders, liver disease, gastro-intestinal surgery or disease (including malabsorption), eating disorders, anaemia, insomnia or cardiovascular disease, and/or any other condition deemed unstable by the study physician * Taking medications known to alter body composition or metabolism, including (but not limited to): any medication used to lower blood glucose or antidiabetic medications (metformin, sulfonylureas, Glucagon-like peptide-1 (GLP-1) analogues \[i.e. exenatide\], thiazolidinediones or DPP-IV inhibitors \[i.e. 'gliptins'\]), medications affecting weight, appetite or gut motility (i.e. diuretics, domperidone, cisapride, orlistat, phentermine, topiramate) * Participants who are taking stable doses (i.e. \> 12 months) of androgenic medications (i.e. testosterone) or SSRI's will not be excluded. Personal history/diagnosis (self-reported) of diabetes (type 1 or 2), major psychiatric disorders (schizophrenia, major depressive disorder, bipolar disorder, eating disorders), gastrointestinal disorders, haematological disorders (i.e. thalassemia, iron-deficiency anaemia) insomnia, or any other medical condition, deemed unstable by the study physician * Pregnant, planning a pregnancy or breastfeeding * Those who have lost or gained \>5% of body weight in the last 6 months * Those who consume four or more standard drinks on a single occasion at a 'daily or almost daily' occurrence * current smokers of cigarettes/marijuana/e-cigarettes/vaporisers * unable to comprehend the study protocol (i.e. due to English language or cognitive difficulties)

Study locations

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.