Recruiting
Effect of Benzalkonium Chloride Preserved and Preservative-free Latanoprost Eye Drops on Conjunctival Goblet Cells
a randomized, investigator-blind, interventinal study will compare the effect of benzalkonium-chloride (BAK) preserved and preservative-free (PF) eye drops on conjunctival goblet cells.
ClinicalTrials.gov IDNCT04957329
PhasePHASE4
Enrollment28
SponsorRigshospitalet, Denmark
Age18 Years
SexALL
Conditions studied
Glaucoma, Ocular Hypertension
About this study
a randomized, investigator-blind, interventinal study will compare the effect of benzalkonium-chloride (BAK) preserved and preservative-free (PF) eye drops on conjunctival goblet cells.
Interventions
- Drug: Xalatan — Eye drop
- Drug: Monoprost — Eye drop
Primary outcomes
- Goblet cell density (3 months)
Eligibility information
Inclusion Criteria:
1. Age \>18years
2. Danish speaking
3. Open angle glaucoma or ocular hypertension
4. Average intraocular pressure equal to or above 22 mmHg
Exclusion Criteria:
a. history of significant eye diseae (including okular trauma) other than open angle glaucoma and ocular hypertension d. treatment with steroids within the last 3 months from inclusion e. Significant untreated systemic disease such as hypertension, heart failure, diabetes mellitus, stroke, lung disease and autoimmune diseases. Diseases are not reason for exclusion if they are well treated or does not need treatment g. pregnant or breast feeding h. women using unsafe anticonception i. allergy towards trial medication j. patients who cannot cooperate in eye examination k. ocular surface defects l. need for polytherapy in glaucoma treatment
Study locations
- Department of ophthalmology, rigshospitalet.glostrup, Glostrup Municipality, Danmark 2600 Denmark
- Department of drug design and pharmacology, University of Copenhagen, Copenhagen, 2100 Denmark
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.