Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)

Conditions studied

Type 2 Diabetes Mellitus, Diabetic Kidney Disease, Adolescent Obesity, Pre Diabetes, Kidney Hypoxia, Puberty

About this study

Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an accelerator of kidney disease in youth with obesity and diabetes and the investigators posit that the link between puberty and T2D-onset may explain the high burden of DKD in youth-onset T2D. A better understanding of the impact of puberty on kidney health is needed to promote preservation of native kidney function, especially in youth with T2D.

Interventions

• Drug: Aminohippurate Sodium Inj 20% — Diagnostic aid/agent used to measure effective renal plasma flow (ERPF)
• Drug: Iohexol Inj 300 MG/ML — Diagnostic aid/agent used to measure glomerular filtration rate (GFR)
• Drug: Dextran 40 — Diagnostic aid/agent used to measure glomerular size and selectivity

Primary outcomes

• Effective renal plasma flow (ERPF) (3 Hours)
• Glomerular Filtration Rate (GFR) (3 hours)

Eligibility information

Study locations

• Children's Hospital Colorado, Aurora, Colorado 80045 United States
• Seattle Children's Hospital, Seattle, Washington 98102 United States