Recruiting
High-dose Vitamin D Supplement for the Prevention of Acute Asthma-like Symptoms in Preschool Children
To investigate whether high-dose vitamin D supplementation may have a beneficial effect on secondary prevention in preschool children (1-5 years of age), with respiratory infections being the primary cause of acute exacerbations with asthma-like symptoms.
ClinicalTrials.gov IDNCT05043116
PhasePHASE2
Enrollment320
SponsorCopenhagen Studies on Asthma in Childhood
Age12 Months
SexALL
Conditions studied
Asthma in Children
About this study
To investigate whether high-dose vitamin D supplementation may have a beneficial effect on secondary prevention in preschool children (1-5 years of age), with respiratory infections being the primary cause of acute exacerbations with asthma-like symptoms.
Interventions
- Dietary Supplement: Cholecalciferol D3 — 2000 IU of Vitamin D provided as oral suspension for one year
- Other: Oral placebo suspension — Oral suspension with no active substance tasting like the active supplement.
Primary outcomes
- Number of acute exacerbations (One year)
Eligibility information
Inclusion Criteria:
The study population consists of children in the age group 1-5 years admitted to a pediatric ward, due to an acute episode with asthma-like symptoms. An acute asthma-like episode will be defined as annoying coughing, wheezing (wheezing or wheezing in connection with exhalation) and / or dyspnoea, which affects the child's well-being and requires hospitalization in a pediatric ward. Participation in the study requires that the child is in or has been in treatment with SABA, as monotherapy, or in combination with ICS, and possibly also in combination with LTRA in accordance with the Danish guidelines
Exclusion Criteria:
* The child is hospitalized with pneumonia
* The child's daily intake of vitamin D supplementation is\> 400 IU / day (\~ 10 μg / day).
* The child is given a combination of vitamin and dietary supplements containing vitamin D, thus the daily recommended dose is exceeded, as 2400 IU / day (\~ 60 μg / day) is accepted for children aged 1-4 years, as everyone here is recommended to take 400 IU / day (\~ 10 μg / day) by the Danish Health and Medicines Authority.
* The baby has been exclusively breastfed for the past 6 months.
* The child is malnourished
* for children\> 2 years of age whose age-specific BMI is less than the 3rd percentile.
* for children \<2 years, whose weight or height in relation to age is less than the 3rd percentile.
* The child is a newly arrived refugee or immigrant from regions with a high risk of rickets.
* The child has other chronic lung diseases.
* The child is diagnosed with other conditions such as chronic lung disease, impaired renal function, neurological or psychiatric disorders, congenital or documented acquired QT prolongation, clinically relevant bradycardia, cardiac arrhythmia or severe heart failure and / or hepatic impairment.
* The child is being treated with medication that alters calcium or vitamin D absorption / metabolism.
Study locations
- University Hospital of Copenhagen, Gentofte Municipality, Gentofte 2820 Denmark
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.