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Deafness and Cognition in Middle-aged Adults

A mild cognitive impairment was observed in 50% of cochlear implant candidates aged 65 years and over, compared to 5-19% in general population. No studies analysed cognition in patients younger than 65 years. The aim of our study was to compare cognitive function between patients with severe and profound hearing loss and patients with normal hearing in patients aged 45 to 64 years.

ClinicalTrials.gov IDNCT05149742

PhaseNA

Enrollment180

SponsorAssistance Publique - Hôpitaux de Paris

Age45 Years

SexALL

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Conditions studied

Mild Cognitive Impairment in Middle-aged Adults

About this study

Interventions

Behavioral: Cognitive and audiometry evaluation — For both Patients and controls: * Cognitive functions evaluation * Tonal and vocal audiometry * Self questionnaires

Primary outcomes

Evaluation of Mini Mental State Examination to access cognitive impairment in patients with severe to profound hearing loss compare to subjects with normal hearing (1 day)
Evaluation of Trail making tests (TMT) A et B to evaluate executive functions in patients with severe to profound hearing loss compare to subjects with normal hearing (1 day)
Evaluation of "Fluences verbales sémantique et phonémique" to evaluate linguistic skills in patients with severe to profound hearing loss compare to subjects with normal hearing (1 day)
Evaluation of 16-item Free and Cue Selective Recall Test (RLRI/16) to evaluate episodic memory in patients with severe to profound hearing loss compare to subjects with normal hearing (1 day)
Evaluation of Digit Symbol Substitution Test to evaluate psychomotor speed and executive functions, executive functions in patients with severe to profound hearing loss compare to subjects with normal hearing (1 day)
Evaluation of Instrumental activities of daily living scale to evaluate the level of dependence of dependence of the subjects in patients with severe to profound hearing loss compare to subjects with normal hearing (1 day)
Evaluation of Cognitive Complaint Questionnaire to evaluate Cognitive assessment in patients with severe to profound hearing loss compare to subjects with normal hearing (1 day)

Eligibility information

Inclusion Criteria: * Cases: Patients aged between 45 to 64 years with severe to profound bilateral post-lingual sensorineural hearing loss with a maximum intelligibility of 70% (disyllabic words) in free-field silence with hearing aids at 60 dB SPL, current in french * Controls: normal hearing subjects matched on age, sex and education level Exclusion Criteria: * Associated disability that prevents the tests from being performed * Past and current history of neurological and psychiatric disorders including meningitis * Psychotropic drug treatment * Vulnerable subject

Study locations

Centre de Recherche en Audiologie (CReA) - Groupe Hospitalier Pitié-Salpêtrière, Paris, 75013 France

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.