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The Effect of Laparoscopic Splenectomy and Azygoportal Disconnection on Liver Reserve Function for Cirrhosis Patients

In this study, the investigators compared the improvement of liver reserve function related indicators in patients with liver cirrhosis after laparoscopic splenectomy and azygoportal disconnection. To determine whether surgical treatment can help enhance postoperative liver reserve function and improve patient prognosis.

ClinicalTrials.gov IDNCT05325437

PhaseNA

Enrollment20

SponsorNorthern Jiangsu People's Hospital

Age18 Years

SexALL

I'm interested View official listing

Conditions studied

Cirrhosis, Liver, Splenectomy; Status, Portal Hypertension

About this study

Interventions

Procedure: Laparoscopic splenectomy and azygoportal disconnection — The laparoscopic splenectomy and azygoportal disconnection was performed by the same surgical team.

Primary outcomes

Liver reserve function ICG-K at 3 months after surgery. (3 months)
Liver reserve function ICG-K at 6 months after surgery. (6 months)
Liver reserve function ICG-K at 12 months after surgery. (12 months)
Liver reserve function ICG-K at 24 months after surgery. (24 months)
Liver reserve function ICG-R 15 at 3 months after surgery. (3 months)
Liver reserve function ICG-R 15 at 6 months after surgery. (6 months)
Liver reserve function ICG-R 15 at 12 months after surgery. (12 months)
Liver reserve function ICG-R 15 at 24 months after surgery. (24 months)

Eligibility information

Inclusion Criteria: * A clinical, radiological or histologic diagnosis of cirrhosis of any etiology * Splenomegaly with secondary hypersplenism * gastroesophageal variceal bleeding * Informed consent to participate in the study Exclusion Criteria: * Hepatocellular carcinoma or any other malignancy, * Child-Pugh grade C * Recent peptic ulcer disease * History of Hemorrhagic stroke * Pregnancy. * Uncontrolled Hypertension * Human immunodeficiency virus (HIV) infection

Study locations

Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu 225001 China

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.