Recruiting
Deep Sclerectomy Versus Trabeculectomy in Normal Tension Glaucoma
The purpose of this study is to assess whether deep sclerectomy is as effective in lowering intraocular pressure (IOP) as trabeculectomy in patients with normal tension glaucoma.
ClinicalTrials.gov IDNCT05371977
PhaseNA
Enrollment80
SponsorHelsinki University Central Hospital
Age55 Years
SexALL
Conditions studied
Normal Tension Glaucoma
About this study
The purpose of this study is to assess whether deep sclerectomy is as effective in lowering intraocular pressure (IOP) as trabeculectomy in patients with normal tension glaucoma.
Interventions
- Procedure: Trabeculectomy — trabeculectomy glaucoma surgery
- Procedure: Deep Sclerectomy — deep sclerectomy glaucoma surgery
Primary outcomes
- Success Rate (One year)
Eligibility information
Inclusion Criteria:
* Signed Informed Consent
* Normal Tension Glaucoma with typical nerve fiber layer defects in red-free photographs and/or optical coherence tomography (OCT) and possible equivalent visual field defects, IOP never more than 21 mmHg, and open anterior chamber angle
* Glaucoma unstable with current medication assessed by a glaucoma specialist
Exclusion Criteria:
* Secondary Glaucoma e.g. due to previous injury or uveitis
* Exfoliation syndrome
* Pigment dispersion syndrome
* Previous transscleral or endoscopic cyclophotocoagulation
* Previous other glaucoma surgery
* Previous retinal detachment
* Previous intraocular surgery like vitrectomy and other retinal surgery
* Wet age-related macular degeneration
* Diabetic retonopathy
* Previous corneal transplant or previous refractive surgery
* Fuchs' dystrophy and other abnormalities compromising corneal clarity like scars
* The patient does not want to participate in the study
* The patient does not speak Finnish, Swedish or English
* Dementia
* Only eye with vision worse than 20/200 or loss of central visual field
Study locations
- Helsinki University Central Hospital, Helsinki, 00990 Finland
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-29.