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The Effect of Hyperoxia on Ventilation During Recovery From General Anesthesia

In this randomized-controlled trial the investigators will examine the effect of oxygen supplementation on the recovery of breathing for 90 minutes in the immediate post-anesthesia period starting from extubation of the trachea.

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ClinicalTrials.gov IDNCT05379673

PhaseNA

Enrollment60

SponsorStanford University

Age18 Years and older

SexALL

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Conditions studied

Ventilatory Depression, Postoperative Respiratory Failure

About this study

Interventions

Other: Oxygen Gas for Inhalation — Oxyhemoglobin saturation (SpO2) higher than 96% vs SpO2 between 90% and 94%.

Primary outcomes

Transcutaneous partial pressure of carbon dioxide (TcPCO2) (Ninety -minute period beginning immediately post-anesthesia.)

Eligibility information

Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status I-III * Body mass index (BMI) less than 40 kg/m2 * Scheduled to undergo robotic-assisted radical laparoscopic nephrectomy or prostatectomy. Exclusion Criteria: * Patients with a diagnosis of chronic obstructive pulmonary disorder (COPD), severe neurological, cardiopulmonary, psychiatric, or untreated thyroid disorder * Chronic pain condition that is being treated with opioids * Patients with a hematocrit lower than 30% at the end of surgery, or those with an excessive blood loss, requiring transfusion of blood products during surgery.

Study locations

Stanford University School of Medicine, Stanford, California 94305 United States

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.