Recruiting
Valuation in Depressed Mood, Anhedonia, and Anxiety
This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.
ClinicalTrials.gov IDNCT05384158
PhaseNA
Enrollment252
SponsorVirginia Polytechnic Institute and State University
Age25 Years
SexALL
Conditions studied
Neurobehavioral Components of Reward and Loss Valuation
About this study
This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.
Interventions
- Behavioral: cognitive behavioral therapy — cognitive behavioral therapy
- Behavioral: valuation with instruction — repeat laboratory sessions of computerized learning game
- Behavioral: valuation without instruction — repeat laboratory sessions of computerized learning game
Primary outcomes
- change in proportion correct on the 'N-arm bandit learning task' (study entrance to study exit, an average of 12 weeks)
Eligibility information
Inclusion Criteria:
* mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.
Exclusion Criteria:
* history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI
Study locations
- Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia 24014 United States
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.