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Renal Nerve Stimulation in Uncontrolled Hypertensive Patients Undergoing Renal Denervation

Study design: Investigator initiated, single center The study is aimed 1\) To investigate the blood pressure (BP) change to renal nerve stimulation(RNS), and subsequently perform a renal denervation(RDN) procedure 1\) to verify the cutoff value (RNS-induced systolic BP change \<20 mmHg in post-RDN patients) could be a useful clinical endpoint in RDN therapy, and test the hypothesis that intense RDN could improve the efficacy of RDN.

ClinicalTrials.gov IDNCT05421767

PhasePHASE4

Enrollment60

SponsorNational Taiwan University Hospital

Age20 Years

SexALL

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Conditions studied

Hypertension

About this study

Interventions

Procedure: nerve stimulation guided renal denervation procedure — RNS-in

Primary outcomes

arterial blood pressure response (during procedure)

Eligibility information

Inclusion Criteria: Patients with hypertension (HTN), including 1. 24-hour ambulatory blood pressure \>130/ 80 mmHg 2. Age 20-80 years 3. Glomerular filtration rate \>45 mL/min Exclusion Criteria: 1. Unsuitable renal artery anatomy computed tomographic angiography (main renal artery lumen diameter ≤3 mm or a total length \<20 mm of the main arteries). 2. untreated secondary HTN, including hyperaldosteronism, pheochromocytoma, renal artery stenosis(\>50% stenosis)

Study locations

National Taiwan University Hospital, Taipei, 100 Taiwan

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-30.