Risk Factors and Multiomics Study of Chronic Kidney Disease Caused by Metabolic Diseases

Conditions studied

Chronic Kidney Diseases, Hypertension, Diabetes Mellitus, Hyperuricemia, Obesity

About this study

With the development of China's economy, people's living standard have improved, and the dietary structure have changed. Metabolic diseases, such as hypertension, diabetes, hyperuricemia and obesity have gradually become an important health burden in China. The pathophysiological mechanism of renal injury caused by metabolic diseases has always been a hotspot of research. Currently, it is believed that various mechanisms including the activation of Renin-Angiotensin-Aldosterone System, vascular endothelial dysfunction, oxidative stress and inflammatory process may be involved. Although there are differences in renal pathological manifestations caused by different metabolic diseases, the kidney will eventually present ischemic changes and fibrosis with the progression of the disease. So there must be some common pathogenesis. This study is designed to build a disease cohort of patients with chronic kidney disease caused by metabolic diseases, to identify risk factors leading to disease progression and to explore biomarkers for early diagnosis and treatment of kidney damage.

Interventions

• Diagnostic Test: Biomarkers — Blood,urine and imaging biomarkers for early diagnosis and prediction of prognosis.

Primary outcomes

• Number of Participants with End Stage Renal Disease (3 years)
• Number of Participants with Adverse cardiovascular events (3 years)
• Number of Participants with all cause death (3 years)

Eligibility information

Study locations

• Peking Union Medical College Hospital, Beijing, Beijing Municipality 100730 China