Recruiting
The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma
Asthma is one of the most common chronic respiratory diseases. Previous study found a series of differentially expressed genes and proteins (transgelin-2, metallothionein-2, ezrin) in asthmatic rat. The aim of the study is to investigate the changes and associations of these gene with asthma in human.
ClinicalTrials.gov IDNCT05496582
PhaseNot Applicable
Enrollment100
SponsorShanghai University of Traditional Chinese Medicine
Age14 Years
SexALL
Conditions studied
Asthma
About this study
Asthma is one of the most common chronic respiratory diseases. Previous study found a series of differentially expressed genes and proteins (transgelin-2, metallothionein-2, ezrin) in asthmatic rat. The aim of the study is to investigate the changes and associations of these gene with asthma in human.
Interventions
- Diagnostic Test: No intervention — No intervention
Primary outcomes
- Difference in gene expression of transgelin-2, metallothionein-2 and ezrin between controls and asthmatic patients (Two year)
- Association of transgelin-2, metallothionein-2 and ezrin with asthma (Two year)
Eligibility information
Inclusion Criteria:
1. Males or females, aged 14-75 years;
2. Patients with a definite diagnosis of bronchial asthma;
3. The diagnosis of asthma according to the Global Initiative for Asthma (GINA), with positive bronchodilator responsiveness (reversibility) test;
4. Healthy volunteers without respiratory symptoms such as cough, wheezing, chest tightness or dyspnea;
5. Agree with all procedures in this trial by signing a written informed consent form.
Exclusion Criteria:
1. Patients with chronic obstructive pulmonary disease or other airway disease;
2. Complicated with other severe primary diseases (including hypertension, cancer, hyperthyroidism, bronchiectasia, cardiac insufficiency) and conditions that would prevent participation in the trial or put the participant at risk;
3. Women who are known to be pregnant or breastfeeding;
4. Not willing to participate;
5. Psychiatric history and neurological disorders can not work normally;
6. Other conditions that the researcher considers inappropriate to participate in this study.
Study locations
- Xiangya Hospital, Central South University, Changsha, Hunan 410000 China
- Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai Municipality 200030 China
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-02.