Mechanisms of Behavioral Activation (BA)
The investigators will be comparing brain (neural) activation of depressed adolescent patients before, during and after a course of Behavioral Activation (BA) therapy using functional magnetic resonance imaging (fMRI). In particular, the project seeks to determine whether BA targets different neural mechanisms for behavioral avoidance associated with low motivation as compared to threat avoidance. A group of healthy controls will also be scanned as a comparator group for behavioral and imaging measures.
Conditions studied
Depression
About this study
The investigators will be comparing brain (neural) activation of depressed adolescent patients before, during and after a course of Behavioral Activation (BA) therapy using functional magnetic resonance imaging (fMRI). In particular, the project seeks to determine whether BA targets different neural mechanisms for behavioral avoidance associated with low motivation as compared to threat avoidance. A group of healthy controls will also be scanned as a comparator group for behavioral and imaging measures.
Interventions
- Behavioral: Behavioral Activation Therapy — Participants will be seen for a maximum of 16 sessions of therapy focused on increasing rewarding behaviors (16 individual therapy sessions of 1-hour, 2 of which include the BSIS component) over 16 weeks. BA intervention includes monthly booster sessions offered throughout 6-month follow up. If needed, two extra sessions will be allowed during treatment.
- Behavioral: Baseline assessment procedures — Completion of the K-SADS and CDRS-R to assess MDD, and the Wechsler Abbreviated Scale of Intelligence - 2nd Edition to assess IQ.
Primary outcomes
- Change in Diagnostic Interview Status (CDRS-R) total score from baseline (Baseline, week 16 post intervention)
- Change in Adolescent Longitudinal Interval Follow-Up Evaluation (A-LIFE) (Week 8 post intervention (Midpoint), week 16 post intervention)
Eligibility information
Study locations
- Emory University, Atlanta, Georgia 30322 United States
- Facility for Education and Research in Neuroscience (FERN), Atlanta, Georgia 30322 United States
- Child and Adolescent Mood Program (CAMP), Atlanta, Georgia 30329 United States
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.