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Therapeutic Mechanisms of Epidural Spinal Cord Stimulation

The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS, and finally 3) whether different SCS waveforms elicits stimulus-evoked compound action potentials (ECAPs) in spinal cord and at the cortex (electroencephalography, and magnetoenchphalography).

ClinicalTrials.gov IDNCT05556902

PhaseNA

Enrollment80

SponsorUniversity of Alabama at Birmingham

Age18 Years – 89 Years

SexALL

I'm interested View official listing

Conditions studied

Blood Pressure, Low Back Pain, Hypertension

About this study

Interventions

Device: Permanent Epidural Spinal Cord Stimulation — Permanent Spinal Cord Stimulation implanted in participants undergoing routine care for management of chronic neuropathic pain.

Primary outcomes

Arterial Blood Pressure Change (Baseline (1 week pre-op))
Arterial Blood Pressure Change (Visit 2 (4-6 weeks post-op))

Eligibility information

Inclusion Criteria: 1. Male or Female, age 18-89 2. Chronic pain for more than 3 months 3. Willing to visit a research lab 4. Willing to undergo a blood draw 5. Able to provide written informed consent Exclusion Criteria 1. History of neurological disease (e.g., dementias, Parkinson's) 2. History of stroke 3. Current diagnosis of cancer 4. Subject is unwilling or unable to comply with the protocol

Study locations

University of Alabama at Birmingham, Birmingham, Alabama 35233 United States

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-16.