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Alteration of Symbiosis Intestinal Microbiota on Patients With Anorexia Nervosa

The purpose of this study will be to study the association between the level of psychic symptomatic of anorexia nervosa (AN) (intensity of food restriction, symptoms of anxiety and depression) and alteration of host environment symbiosis and the mechanism (dysbiosis of intestinal microbiota, increase of intestinal permeability, immunity alteration and low-grade inflammation).

ClinicalTrials.gov IDNCT05632497

PhaseNot Applicable

Enrollment120

SponsorAssistance Publique - Hôpitaux de Paris

Age18 Years

SexALL

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Conditions studied

Anorexia Nervosa, Dysbiosis, Anxious Depression

About this study

Interventions

Biological: Stool and blood samples — Stool and blood samples

Primary outcomes

Eating Disorder (at baseline)
Anxio-depressive symptomatologic assessements by HAD score (at baseline)
Anxio-depressive symptomatologic assessements by scale of Beck BDI 13 (at baseline)
Anxio-depressive symptomatologic assessements by LSAS Lieboweitz social anxiety scale (at baseline)
Anxio-depressive symptomatologic assessements by MOCI (at baseline)
Anxio-depressive symptomatologic assessements (at baseline)
Physical exercise (at baseline)
Biological parameter (at baseline)

Eligibility information

Inclusion Criteria: For patients: * Patients aged ≥18 years; * Anorexia according to DSM-5 and CIDI (Composite International Diagnostic Interview); * Body mass index (BMI) (P/T2) \< 15; * Hospitalization for nutrition rehabilitation; * Covered by a health insurance; * Informed consent form signed. For Healthy Volunteers: * Aged ≥18 years; * 18.5 \< BMI (P/T2) \< 25; * Covered by a health insurance; * Informed consent form signed. Exclusion Criteria: For patients: * Patients no-responding all criteria of DSM-5 or CIDI scores; * Taken of antibiotic treatment 2 months / or laxativ 3 weeks before hospitalization; * Somatic comorbidity should perturb intestinal microbiota (Crohn's disease, diabetes and all other chronic inflammatory diseases); * Patients under guardianship; * Patients covered by french AME scheme. For Healthy Volunteers: * Any disease should perturb intestinal microbiota; * Recent ponderal variation; * Taken of antibiotic treatment 2 months or laxativ 3 weeks before hospitalization; * Under guardianship; * Covered by french AME scheme.

Study locations

Service de Nutrition Clinique, Hôpital Paul Brousse (APHP), Villejuif, 94800 France

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-28.