Recruiting
Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood
The purpose of this study is to understand more about why young people who were born to a hypertensive pregnancy may have increased risk of high blood pressure and are often at increased risk of heart and blood vessel disease later in life.
ClinicalTrials.gov IDNCT05683093
PhaseNot Applicable
Enrollment200
SponsorUniversity of Oxford
Age30 Years
SexALL
Conditions studied
Young Adult, Hypertension in Pregnancy, Hypertension, Cardiovascular Diseases, Cerebrovascular Diseases, Vascular Diseases
About this study
The purpose of this study is to understand more about why young people who were born to a hypertensive pregnancy may have increased risk of high blood pressure and are often at increased risk of heart and blood vessel disease later in life.
Interventions
- Other: History of being born to hypertensive or normal pregnancy — CLARITY is an observational study whereby participants will attend one 4-hr visit the Division of Cardiovascular Medicine, University of Oxford at the John Radcliffe Hospital in Oxford, with the option to split the study visit over two days for convenience. Participants will be invited by the ALSPAC study team to attend a study visit in Oxford where the investigators will use MRI and other imaging modalities to study the brain, heart, liver, kidneys, and vasculature using standardised protocols. A dataset including information from previous follow-up of these cohorts and the detailed pregnancy data available within ALSPAC will be generated by the study team in Bristol and integrated with available data from the Oxford cohorts.
Primary outcomes
- Cardiac right ventricular mass (30-40 years of old)
Eligibility information
Inclusion Criteria:
* Participant is willing and able to give informed consent for participation in the study
* Male or female, aged 30 to 40 years at time of enrolment
* Participant previously took part in the ALSPAC study
* Able (in the investigator's opinion) and willing to comply with all study requirements
* Adequate understanding of verbal and written English
Exclusion Criteria:
* Pregnant or lactating when they are due to attend for study visit 1
* Less than six months postpartum
* Planning to donate blood within two weeks prior to study visit 1
* Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study
* Evidence of congenital heart disease or significant chronic disease relevant to cardiovascular or metabolic status
For exclusion of MRI component only:
* Unsuitable for MRI based on participant screening; the participant may still be included in other parts of the study
Study locations
- University of Oxford, Oxford, Oxfordshire OX3 9DU United Kingdom
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.