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Personalized Mobile Cognitive Behavioral Therapy Application

This study aims to compare the effectiveness of a standard mobile cognitive behavioral therapy program to a personalized mobile cognitive behavioral therapy program that introduces new skills over a shorter period of time. Participants will use the Maya app for two days per week, at least 20 minutes per day, for six weeks. Assessments will include a weekly check in with a member of the research team, questionnaires, and optional electroencephalographic (EEG) recordings at the beginning and end of the 6-week…

ClinicalTrials.gov IDNCT05699525

PhaseNA

Enrollment100

SponsorWeill Medical College of Cornell University

Age18 Years – 25 Years

SexALL

I'm interested View official listing

Conditions studied

Anxiety Disorders and Symptoms, Depression, Bipolar Disorder, Symptoms

About this study

Interventions

Behavioral: Personalized MAYA Mobile App — All new material in the personalized condition will be introduced within the first four weeks and will contain modules targeting participant's personal symptom profiles. The remaining two weeks in the personalized condition will consist of practicing previously learned skills.
Behavioral: General MAYA Mobile App — New material will be introduced to participants over all the six weeks of the intervention and will include all application modules.

Primary outcomes

Change in anxiety symptoms from pre-intervention to post-intervention as measured by the HAM-A. (Baseline to endpoint [Week 6])
Change in depressive symptoms from pre-intervention to post-intervention as measured by HAM-D. (Baseline to endpoint [Week 6])
Change in anxiety symptoms from pre-intervention to post-intervention as measured by the anxiety subscale of the DASS. (Baseline to endpoint [Week 6])
Change in depressive symptoms from pre-intervention to post-intervention as measured by the depression subscale of the DASS. (Baseline to endpoint [Week 6])

Eligibility information

Inclusion Criteria: * Age between 18 and 25 years. * Primary diagnosis of an anxiety, depressive, or bipolar disorder as determined by a score of 4 or greater on the Clinical Severity Rating of the Anxiety Disorders Interview Schedule (ADIS). * If an individual is diagnosed with bipolar disorder, they must be currently euthymic or experiencing a depressive episode. * Access to an Apple iPhone, iPad, or Android device. Exclusion Criteria: * History of neurologic disorder that may affect the neural systems of interest or participant's ability to participate * Lifetime diagnosis of a psychotic disorder. * Current hypomanic or manic episode. * Currently in cognitive behavior therapy. * Change in dose of a psychiatric medication in the past 12 weeks. * Initiation of psychotherapy in the past 12 weeks. * Intent or plan to attempt suicide.

Study locations

Weill Cornell Medical College, New York, New York 10065 United States

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-16.