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Type 2 Diabetes, Obesity and Cortisol Excess

The present observational cross-sectional study is aimed to assess: the hidden hypercortisolism (HidHyCo) prevalence in a sample of Type 2 diabetes (T2D) patients and the clinical characteristics more frequently associated with the HidHyCo presence and the HidHyCo prevalence in an adequate sample of obese patients without T2D and the clinical characteristics more frequently associated with the HidHyCo presence.

ClinicalTrials.gov IDNCT05759637

PhaseNot Applicable

Enrollment3200

SponsorIstituto Auxologico Italiano

Age18 Years

SexALL

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Conditions studied

Diabetes Mellitus, Type 2, Obesity, Cortisol; Hypersecretion

About this study

Interventions

Diagnostic Test: 1mg DST — measurement of cortisol levels after 1 mg of dexamethasone (DST) at 11 pm

Primary outcomes

Hidden Hypercortisolism prevalence in a sample of T2D patients (24 months)
Hidden Hypercortisolism prevalence in a sample of Obese patients (24 months)

Eligibility information

Inclusion Criteria: patients with T2D and Obesity Exclusion Criteria: * pregnancy/breast feeding, * sleep apnea, * prepuberal onset of hypertension, hormonal hypersecreting adrenal mass, * symptoms of hypercortisolism; * already known secondary hypertension; * conditions associated with increased hypothalamic-pituitary-adrenal (HPA) axis activity, -severe autoimmune/rheumatologic and hematologic diseases, alcoholism, kidney disease (glomerular filtration rate \<60) * drugs influencing the HPA axis activity. For inclusion in Group 2 the presence of T2D will be an exclusion criteria

Study locations

Istituto Auxologico Italiano, Milan, 20135 Italy
Niguarda Hospital, Milan, 20162 Italy
Campus Bio-Medico University, Roma, 00128 Italy
University of Siena, Siena, 53100 Italy
Azienda Ospedaliero Universitaria, Santa Maria della Misericordia di Udine, Udine, 33100 Italy

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-03.