Recruiting
Diagnosing Variable Primary Aldosteronism.
The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.
ClinicalTrials.gov IDNCT05765786
PhaseNot Applicable
Enrollment100
SponsorQueen Mary University of London
Age18 Years
SexALL
Conditions studied
Primary Aldosteronism, High Blood Pressure
About this study
The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.
Primary outcomes
- Sensitivity and specificity of 24 hour urine tetrahydroaldosterone excretion. (12 months)
Eligibility information
Inclusion Criteria:
* People with clinically suspected PA but have not met criteria for diagnosis. Suspicion based on low-renin (renin activity \<0.5 nmol/h/L or renin mass \<5 ng/L), plasma sodium \> 140mmol/L or plasma potassium \< 4mmol/L.
* Patients who have been diagnosed with PA and had previous aldosterone samples \<277 pmol/L, a level which would normally not qualify for confirmatory testing.
* Patients with aldosterone results done at different times that indicate variability in production.
* Willing to consent and participate in the study.
Exclusion Criteria:
* Inability to withdraw β-adrenoceptor antagonist therapy for 2 weeks.
* People on end of life treatment.
Study locations
- Queen Mary University of London, London, United Kingdom
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.