Recruiting

Home-based Respiratory Muscle Training for Minimizing Side Effects in Patients Undergoing Treatment for Cancer

ClinicalTrials.gov IDNCT05787834

PhaseNA

Enrollment130

SponsorRoswell Park Cancer Institute

Age21 Years

SexALL

I'm interested View official listing

Conditions studied

Breast Carcinoma, Head and Neck Cancer, Lung Cancer

About this study

This clinical trial evaluates whether home-based respiratory muscle training is useful for minimizing side effects in patients undergoing treatment for cancer. Over-activation of the nervous system during breast cancer treatment can result in heart- and lung-related side effects which have the potential to reduce a patient's quality of life. Aerobic exercise can help prevent the development of these side effects. However, engaging in regular aerobic exercise may be difficult for breast cancer patients who are actively undergoing treatment. Respiratory muscle training (RMT) involves a series of breathing and other exercises that are performed to improve the function of the respiratory muscles through resistance and endurance training. Home-based RMT may represent a more feasible approach for reducing side effects in patients undergoing treatment for breast cancer.

Interventions

Other: Best Practice — Receive usual care
Other: Medical Device Usage and Evaluation — Wear accelerometer
Procedure: Respiratory Muscle Training — Undergo RMT
Other: Survey Administration — Ancillary studies

Primary outcomes

Proportion of patients who participate in the study (Up to 12 weeks)
Proportion of patients who remain on study (Up to 12 weeks)
Proportion of patients who perform >= 3 respiratory muscle training (RMT) sessions/week (Up to 12 weeks)
Proportion of patients who perform > 70% of their RMT sessions (Up to 12 weeks)

Eligibility information

Inclusion Criteria: * Able and willing to provide written informed consent * Age \>= 21 years old * Diagnosed with solid tumor (e.g., head and neck, thoracic, or breast cancer) * Scheduled to receive at least one dose of chemotherapy or immunotherapy or radiation * Treated at Roswell Park Comprehensive Cancer Center Exclusion Criteria: * Presence of oral mucosal disease including oral mucositis, or oral candidiasis detected at baseline * Have uncontrolled intercurrent illness including, but not limited to, ongoing or active respiratory infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, heart failure or psychiatric illness/social situations that would limit compliance with study requirements * Any condition which in the Investigator's opinion deems the participant an unsuitable candidate to receive study intervention

Study locations

Roswell Park Cancer Institute, Buffalo, New York 14263 United States

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.