Recruiting

Nanodropper Use in Primary Open-Angle Glaucoma Patients: A Non-Inferiority Trial

This randomized, single-masked, crossover, non-inferiority trial aims to evaluate the safety and efficacy of Nanodropper-mediated microdrops of ocular hypotensive topical treatments (experimental intervention) compared to standard drops of the same medication(s) (active comparator) in Wilford Hall Ambulatory Surgical Center (WHASC) primary open-angle glaucoma (POAG) and ocular hypertension (OHTN) patients.

ClinicalTrials.gov IDNCT05844384

PhaseNA

Enrollment30

Sponsor59th Medical Wing

Age18 Years and older

SexALL

I'm interested View official listing

Conditions studied

Ocular Hypertension, Primary Open Angle Glaucoma

About this study

Interventions

Device: Nanodropper — Nanodropper delivers 1/5 of eye drop volume compared to regular droppers
Device: Regular dropper — Delivers full eye drop volume

Primary outcomes

Change from baseline in mean intraocular pressure at 6 month (Change from baseline to month 6)

Eligibility information

Inclusion Criteria: * POAG/OHTN patients above the age of 18 years. * On a maximum of 2 IOP lowering medications. * Stable disease without progression in IOP, optic disc cupping, RNFL changes, and visual field changes within the previous 1 year. Exclusion Criteria: * Glaucoma not of the POAG or OHTN variety or other retinal diseases. * Progression of disease within the preceding 1 year (IOP elevation, optic disc cupping, visual field changes). * Using more than 2 IOP-lowering medications. * IOP-lowering surgical interventions or lasers except for SLT. SLT may have been completed 6+ months prior to study start date.

Study locations

Wilford Hall Ambulatory Surgical Center, Lackland Air Force Base, Texas 78236 United States

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-11-03.