Glaucoma Rehabilitation Using ElectricAI Transcranial Stimulation (GREAT) - Randomized Controlled Trial Using Combined Perceptual Learning and Transcranial Electrical Stimulation for Vision Enhancement
Glaucoma is a complex disease that can result in progressive vision loss. It is the second leading cause of blindness, accounting for 23% of permanent blindness in Hong Kong. There are no treatments that restore vision lost to glaucoma. However, recent studies have shown that vision can be improved by perceptual learning (PL) and transcranial electrical stimulation (tES). This study will examine the effect of perceptual learning and tES on improving quality of life, visual function and functional performance in…
Conditions studied
Glaucoma
About this study
Glaucoma is a complex disease that can result in progressive vision loss. It is the second leading cause of blindness, accounting for 23% of permanent blindness in Hong Kong. There are no treatments that restore vision lost to glaucoma. However, recent studies have shown that vision can be improved by perceptual learning (PL) and transcranial electrical stimulation (tES). This study will examine the effect of perceptual learning and tES on improving quality of life, visual function and functional performance in patients with peripheral field loss due to glaucoma. It is phase 2 of Glaucoma Rehabilitation Using ElectricAI Transcranial Stimulation (GREAT) project.
Interventions
- Other: Real-PL training + Real-tES(tDCS) — PLtraining : around 40mins, tDCS: 20mins
- Other: Real-PL training + Sham-tES (tDCS) — PL training : around 40mins, tDCS: 20mins
- Other: Placebo-PL training + Sham-tES (tDCS) — PL training : around 40mins, tDCS: 20mins
Primary outcomes
- Visual field test (Change from baseline at 5weeks, change from baseline at 10weeks, change from baseline at 15weeks, change from baseline at 19weeks, changes from baseline at 23weeks)
Eligibility information
Study locations
- The Hong Kong Polytechnic University, Hong Kong, Hong Kong
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.