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Physical Activity and Cardiovascular Profile of Pre-conceptional Women At Risk for GHD

To compare the cardiovascular profile of pre-conceptional women at risk for developing Gestational Hypertensive Disorders in subsequent pregnancy before and after physical activity.

ClinicalTrials.gov IDNCT05888467

PhaseNA

Enrollment140

SponsorHasselt University

Age18 Years

SexFEMALE

I'm interested View official listing

Conditions studied

Gestational Hypertension, Cardiovascular Pregnancy Complication

About this study

To compare the cardiovascular profile of pre-conceptional women at risk for developing Gestational Hypertensive Disorders in subsequent pregnancy before and after physical activity.

Interventions

Other: supervised infrared exercise group — Participants of the intervention group will be asked to perform 1-3 exercise sessions per week at the Infraligne center of Genk, Hasselt or Maasmechelen for a total duration of 12 weeks. During the exercise session, the participant is assigned to an individual 'sport cabin' in which they are standardly exposed to infrared light.
Other: supervised non-infrared exercise group — Participants of the intervention group will be asked to perform 1-3 exercise sessions per week at the Infraligne center of Genk, Hasselt or Maasmechelen for a total duration of 12 weeks. Participants assigned to the supervised non-infrared exercise group will exercise in the sport-cabin with the infrared light turned off.
Other: Control group — Participants of the control group are advised to perform moderate intensity aerobic exercise at least 3 days per week for an average of 30-50 minutes per session and a total duration of 12 weeks.

Primary outcomes

Change in cardiac output level from Baseline at week 12 visit (Baseline and week 12)

Eligibility information

Inclusion Criteria: * Women at risk for the development of GHD in subsequent pregnancy based on the presence of at least one of the following risk factors: * high body mass index (BMI\>30 kg/m²) * a family history of PE (mother, sister) * in the need of assisted reproduction techniques in a previous or subsequent pregnancy * maternal comorbidities: prior PE, diabetes mellitus, chronic hypertension, chronic kidney disease or antiphospholipid syndrome * Non-pregnant (as confirmed by a negative pregnancy urine dipstick test) * Age ≥ 18 years * Being able to understand the Dutch language Exclusion Criteria: Participants eligible for this study must not meet any of the following criteria: * Pregnant at inclusion * Not being able to exercise according to physician's decision * Suffering from underlying diseases that can affect the CV profile such as oncological diseases coronary heart disease, aortic disease, peripheral arterial disease * Participating in another clinical study that may alter the results of this study

Study locations

Hasselt University, Diepenbeek, Limburg 3590 Belgium

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-30.