Recruiting

Cortisol, Hippocampus, and Insula in Anorexia Nervosa.

EXCENTRICC is a platform for scientific collaboration between different disciplines, all working on a common theme: adrenocortical hormones. In this EXCENTRICC sub-study, associations are studied between cortisol levels and depression, anxiety, disease severity and hippocampal and insula volume in the brain in anorexia nervosa.

ClinicalTrials.gov IDNCT05931549

PhaseNot Applicable

Enrollment80

SponsorOdense University Hospital

Age18 Years – 50 Years

SexFEMALE

I'm interested View official listing

Conditions studied

Anorexia Nervosa, Stress

About this study

Primary outcomes

Hippocampus total volumen (cm3) (Cross sectional (AN patients during a treatment course))
Insula total volumen (cm3) ((AN patients during a treatment course))
Plasma cortisol level (mmol/l) (AN patients during a treatment course at any time in relation to the duration of the illness and course of treatment.)
Cortisol diurnal excretion (nmol/d) (AN patients during a treatment course at any time in relation to the duration of the illness and course of treatment.)

Eligibility information

Inclusion Criteria: 1. Women who fulfill the criteria for AN according to the Diagnostic and Statistical Manual of Mental Disorders (DSM), version 5 (APA, 2013). 2. BMI \< 16. Exclusion Criteria: 1. Current treatment with glucocorticoids. 2. Current use of oral contraceptives. 3. Unstable acute somatic comorbidity, e.g., infection. 4. Any kind of metal prostheses or -implants.

Study locations

Odense University Hospital, Odense, 5000 Denmark

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-27.