Identifying and Treating Depression in the Orthopaedic Trauma Population
The goal of this trial is to pilot a way for orthopaedic surgeons to safely screen for depression and provide treatment for depression with medication. The main questions it aims to answer are: 1. What are the outcomes of patients who screen positive for depressive symptoms and are prescribed either an Selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI). 2. What are the outcomes of patients who screen positive for depressive symptoms and choose not to pursue…
Conditions studied
Depression
About this study
The goal of this trial is to pilot a way for orthopaedic surgeons to safely screen for depression and provide treatment for depression with medication. The main questions it aims to answer are: 1. What are the outcomes of patients who screen positive for depressive symptoms and are prescribed either an Selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI). 2. What are the outcomes of patients who screen positive for depressive symptoms and choose not to pursue treatment with medication?
Interventions
- Drug: Fluoxetine 20 MG — Fluoxetine 20 mg once daily
- Drug: Duloxetine 30 MG — Duloxetine 30 mg once daily
- Other: Observation — Referral to behavioral health and resources for addressing depressive symptoms
Primary outcomes
- Depressive Symptom Scores (Baseline)
- Depressive Symptom Scores (Month 3)
- Depressive Symptom Scores (Month 6)
- Depressive Symptom Scores (Month 9)
- Depressive Symptom Scores (Year 1)
Eligibility information
Study locations
- Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157 United States
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.