Recruiting

National Blood Pressure Screening in Children to Improve Paediatric Healthcare in South Africa

ClinicalTrials.gov IDNCT05982847

PhaseNot Applicable

Enrollment22464

SponsorNorth-West University, South Africa

Age5 Years

SexALL

I'm interested View official listing

Conditions studied

Hypertension, Obesity, Adolescent, Obesity, Childhood

About this study

The Childhood Hypertension Consortium of South Africa (CHCSA) was established to foster relationships between the healthcare sector and schools through community engagement and outreach as well as contributing to the decolonization of normative paediatric blood pressure reference values. To date, there has been no nation-wide project in South Africa to determine nationally representative normal blood pressure reference values, nor to estimate the true prevalence of hypertension in the paediatric population of the country. This study will provide critical information on the understanding of blood pressure and hypertension in children, especially of African ancestry. Not only will this effort contribute to the development of the first nationally representative normal reference values of blood pressure but will also benefit healthcare providers in the sector with a clear guideline on the management of high blood pressure in children as developed by experts working with these challenges daily.

Interventions

Diagnostic Test: Blood pressure screening — Blood pressure and anthropometric measurements will be performed in children and adolescents between ages 5-18 years to develop South African nomograms that will aid in the development of clinical practice guidelines to optimise hypertension care in South Africa youth.

Primary outcomes

To determine and compute nationally representative normative reference values for blood pressure in children (Through study completion, an average of 1 year)
To determine and compute nationally representative normative reference values for blood pressure in children (Through study completion, an average of 1 year)
To develop clinical practice guidelines for the management of childhood hypertension in South Africa (Through study completion, an average of 1 year)

Eligibility information

Inclusion Criteria: * All children between ages 5-\<18 years * All children with voluntary assent/consent and parent's permission Exclusion Criteria: * circumstances interfere with the participant's ability to give informed consent (diminished understanding or comprehension, or any language barriers that may pose potential risk in participation under false expectations) * randomly selected children who choose not to participate (lack of assent/consent), even if parent's permission was received, * conditions that interfere with a patient's ability to follow study guidelines, e.g., the use of drugs, alcohol or tobacco products * ages \>18 years or under 5 years * Children will be excluded from the analysis for the determination of normative reference values for blood pressure and anthropometry if taking certain concomitant medication(s) that may affect their blood pressure, or any underlying disease e.g., chronic kidney disease, chronic heart disease etc. that may raise blood pressure.

Study locations

Walter Sisulu University, Mthatha, Eastern Cape South Africa
Nelson Mandela Metropolitan University, Port Elizabeth, Eastern Cape South Africa
University of the Free State, Bloemfontein, Free State South Africa
University of the Witwatersrand, Johannesburg, Gauteng South Africa
University of KwaZulu-Natal, Durban, KwaZulu-Natal South Africa
University of Limpopo, Polokwane, Limpopo South Africa
Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, North West 2531 South Africa
Red Cross War Memorial Children Hospital, Cape Town, Western Cape South Africa
South African Medical Research Council, Cape Town, Western Cape South Africa
University of Cape Town, Cape Town, Western Cape South Africa

Showing 10 of 11 reported sites. See the official listing for all locations.

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.