Recruiting
The Daytime Circadian Rhythm in Exhaled Volatile Organic Compounds in People Living Without and Diabetes
Exhaled volatile organic compounds will be measured during daytime with the goal to identifying circadian variability. The study incudes three subgroups: people without diabetes, people with type 1 diabetes, and people with type 2 diabetes. A total of 60 people will be recruited for the study.
ClinicalTrials.gov IDNCT05984979
PhaseNot Applicable
Enrollment60
SponsorUniversity of Bern
Age18 Years and older
SexALL
Conditions studied
Diabetes Mellitus
About this study
Exhaled volatile organic compounds will be measured during daytime with the goal to identifying circadian variability. The study incudes three subgroups: people without diabetes, people with type 1 diabetes, and people with type 2 diabetes. A total of 60 people will be recruited for the study.
Interventions
- Other: Standardized meal — The participants will receive a standardized meal for breakfast
Primary outcomes
- VOC Patterns over time as gallery plots (During the study procedure (approximately 8 hours))
- VOC Patterns over time as boxplots (During the study procedure (approximately 8 hours))
Eligibility information
Inclusion criteria
Subgroup 1:
* Age 18 or older
* HbA1c below 6.5%
* Written informed consent
Subgroup 2:
* Age 18 or older
* T1D (Type 1 diabetes) with MDI (multiple daily injection) or CSII (Continuous subcutaneous insulin infusion therapy) therapy \>1 year
* Written informed consent
Subgroup 3
* Age 18 or older
* T2D (Type 2 diabetes) with oral antidiabetic medication or insulin therapy
* Written informed consent
Exclusion criteria
* Pregnancy or breastfeeding
* Smoking (last cigarette less than 6 months ago)
* Any chronical lung and intestinal disease diagnosis (such as intestinal bowel disease (IBD); asthma; COPD (chronic obstructive pulmonary disease); lung cancer, …)
* Coeliac disease
* Lactose and fructose intolerance
* Any acute disease diagnosis (such as viral or bacterial infection)
* Drinking habit of more than four units of alcohol per day
* Current inhaled medicines treatments
* Antibiotic treatment in the previous 4 months
Study locations
- University of Bern, Bern, 3010 Switzerland
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-23.