Amplification of Positivity for Alcohol Use
The proposed study consists of two phases. During Phase 1, the investigators will recruit a small sample of participants to complete a psychosocial intervention termed Amplification of Positivity (AMP) for individuals experiencing comorbid depression or anxiety disorders and alcohol use disorder (AMP-A). These participants will be asked to provide both qualitative and quantitative input about the AMP-A intervention. Based on their input and clinician input, the AMP-A manual will be modified for use in Phase 2. The…
Conditions studied
Alcohol Use Disorder, Anxiety, Depression
About this study
The proposed study consists of two phases. During Phase 1, the investigators will recruit a small sample of participants to complete a psychosocial intervention termed Amplification of Positivity (AMP) for individuals experiencing comorbid depression or anxiety disorders and alcohol use disorder (AMP-A). These participants will be asked to provide both qualitative and quantitative input about the AMP-A intervention. Based on their input and clinician input, the AMP-A manual will be modified for use in Phase 2. The goal is to recruit up to 20 participants in order to ensure there will be at least 8 participants who complete all sessions of AMP-A. Phase 2 is a randomized clinical trial (RCT) protocol in which individuals experiencing comorbid depression or anxiety disorders and alcohol use disorder will be randomized to complete AMP-A or an evidence-based cognitive-behavioral therapy (CBT) intervention. Up to 100 participants will be recruited in order to reach a target of N=60. Assessed outcomes will include participant acceptability and completion rates, participant compliance with the intervention, positive and negative affect, substance use- and depression and anxiety-related symptom severity, functional disability, and neural reactivity to reward and alcohol cues during functional magnetic resonance imaging (fMRI).
Interventions
- Behavioral: Cognitive Behavioral Therapy — Cognitive Behavioral Therapy
- Behavioral: Amplification of Positivity Therapy — Amplification of Positivity Therapy
- Behavioral: Surveys and Interviews — Participants will answer questions regarding their mental and physical health as well as their substance use on the computer and in an interview format.
Primary outcomes
- Perceived acceptability and satisfaction of the intervention as measured with the Adherence and Acceptability Scale (AAS) (Average of total scores from the following time points: pre-treatment, 2 weeks after starting treatment, 6 weeks after starting treatment, and at post-treatment (average of 16 weeks after baseline assessment))
- Change in positive affect self-report measured with National Institute of Health (NIH) Patient Reported Outcome Measurement and Information System (PROMIS) Positive Affect score (Trajectory of change from pre-treatment to post-treatment (last time point assessed on average 16 weeks after baseline assessment))
- Change in number of drinking days in the past month (Trajectory of change from pre-treatment to post-treatment (last time point assessed on average 16 weeks after baseline assessment))
Eligibility information
Study locations
- Laureate Institute for Brain Research, Tulsa, Oklahoma 74008 United States
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.