Treating Major Depression With Yoga Mono-therapy
The goal of this single-center, single-blind, randomized, controlled, parallel group, interventional trial is to evaluate antidepressant efficacy of yoga monotherapy of 12-weeks duration in 180 adults meeting diagnostic criteria for mild-to-moderate major depression at the Zuckerberg San Francisco General Hospital. Researchers will compare the yoga interventions to an education control intervention on holistic healthcare.
Conditions studied
Depression Mild, Depression Moderate
About this study
The goal of this single-center, single-blind, randomized, controlled, parallel group, interventional trial is to evaluate antidepressant efficacy of yoga monotherapy of 12-weeks duration in 180 adults meeting diagnostic criteria for mild-to-moderate major depression at the Zuckerberg San Francisco General Hospital. Researchers will compare the yoga interventions to an education control intervention on holistic healthcare.
Interventions
- Behavioral: Yoga practice — 90-minute group yoga classes twice weekly for 12 weeks.
- Behavioral: Education — 90-minute group education classes twice weekly for 12 weeks to learn holistic healthcare modules.
Primary outcomes
- Change in Beck Depression Inventory-II score (Baseline, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks and 12 weeks)
Eligibility information
Study locations
- Zuckerberg San Francisco General Hospital, San Francisco, California 94110 United States
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.