Recruiting

The Advance Project - Advancing Sleep Timing to Improve Depression

150 patients with moderate to severe depression, recently discharged from a psychiatric ward and now recieving treatment at an outpatient unit at Mental Health Center Copenhagen, will be randomised in to two groups. A treatment ad usual (TAU) group and an Advance-group. The Advance-group will receive a psychotherapeutic intervention focusing on advancing sleep timing to improve depression.

ClinicalTrials.gov IDNCT06097221

PhaseNA

Enrollment150

SponsorUniversity Hospital Bispebjerg and Frederiksberg

Age18 Years

SexALL

I'm interested View official listing

Conditions studied

Depression

About this study

Interventions

Behavioral: CRT-Advance — Psychotherapy with focus on advancing sleep timing, using diaries on sleep and zeitgebers.
Behavioral: Treatment as usual — Treatment as usual in the outpatient psychiatric unit.

Primary outcomes

Beck Depression Inventory II (BDI-II) (at inclusion, at two weeks, at fourweeks, at six weeks, and at endpoint (after eight weeks))

Eligibility information

Inclusion Criteria: * Moderate to major depression (DSM-V) * Discharge from psychiatric ward within last 30 days * Sleep onset and/or sleep off-set delayed minimum 1 hour based on the last three days, comparred to sleep in the last week of admittance at the psychiatric ward. Exclusion Criteria: * Psychotic depression. * Cognitive problems making participation difficult. * Substance abuse (e.g. alcohol). * Increased suicidal risk.

Study locations

Mental Health Center Copenhagen, Copenhagen, Frederiksberg 2000 Denmark

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-01.