Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) Longer Term Follow Up

Conditions studied

Asthma, Pulmonary Function, Wheezing, In Utero Nicotine

About this study

The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function at 10 years of age in their offspring. This is an additional continuation of the Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) trial, to follow the offspring through 10 years of age. The hypothesis for this protocol is an extension of the VCSIP trial that supplemental vitamin C in pregnant smokers can significantly improve their children's airway function tests. The investigators aim to demonstrate sustained improvement in airway/pulmonary function and trajectory through 10 years of age.

Interventions

• Dietary Supplement: No active intervention in this protocol (previously randomized to Vitamin C) — In the original VCSIP study, pregnant women were randomized to receive either extra Vitamin C every day (500mg/day) or placebo. This trial is a follow-up trial with no active intervention.
• Other: No active intervention in this protocol (previously randomized to Placebo) — In the original VCSIP study, pregnant women were randomized to receive either extra Vitamin C every day (500mg/day) or placebo. This trial is a follow-up trial with no active intervention.

Primary outcomes

• Sustained improvement in pulmonary function and trajectory (10 years of age)

Eligibility information

Study locations

• Indiana University, Indianapolis, Indiana 46902 United States
• Oregon Health and Science University (OHSU), Portland, Oregon 97217 United States