Oral Health and Adverse Pregnancy Complications
Pregnant women are susceptible to develop periodontitis, but these oral health changes related to pregnancy are often neglected. Periodontitis is accompanied by a low-grade systemic inflammation and can be harmful to the general health of the woman, contribute to pre-term birth and adversely influence the future health and metabolism of the offspring. Despite this, studies indicate that 40% of Danish women in childbearing age do not visit a dentist regularly. The PROBE controlled intervention study will…
Conditions studied
Periodontal Diseases, Pregnancy Complications, Pregnancy Preterm, Gestational Diabetes, Preeclampsia, Inflammation
About this study
Pregnant women are susceptible to develop periodontitis, but these oral health changes related to pregnancy are often neglected. Periodontitis is accompanied by a low-grade systemic inflammation and can be harmful to the general health of the woman, contribute to pre-term birth and adversely influence the future health and metabolism of the offspring. Despite this, studies indicate that 40% of Danish women in childbearing age do not visit a dentist regularly. The PROBE controlled intervention study will investigate the beneficial effect of treatment of periodontal disease during pregnancy on fetal growth, preterm delivery and birth weight.
Interventions
- Other: Periodontal treatment — Periodontal treatment
Primary outcomes
- Prevalence of preterm birth (18 months)
- Prevalence of low birthweight (18 months)
- Increased risk markers for preeclampsia (18 months)
- Prevalence of gestational diabetes (18 months)
Eligibility information
Study locations
- Holbaek Hospital, Holbæk, Holbaek 4300 Denmark
- Holbæk Hospital, Holbæk, Holbaek 4300 Denmark
- Nykøbing Falster Hospital, Nykøbing Falster, Nykøbing Falster 4800 Denmark
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.