Recruiting
EXERT-BCH Exercise Regimen to Improve Muscle Mass After Treatment of Breast Cancer
The purpose of this research study is to evaluate the outcomes of two standard of care group exercise regimens to increase muscle mass in women who have been treated with breast cancer.
ClinicalTrials.gov IDNCT06115486
PhaseNA
Enrollment30
SponsorAllegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Age20 Years
SexFEMALE
Conditions studied
Breast Cancer, Breast Carcinoma in Situ, Breast Cancer Female
About this study
The purpose of this research study is to evaluate the outcomes of two standard of care group exercise regimens to increase muscle mass in women who have been treated with breast cancer.
Interventions
- Other: Control Arm ACSM Guidelines — The control group will follow resistance training guidelines from the American College of Sports Medicine. Eight to ten multi-joint exercises will be performed to stress the major muscle groups.
- Other: Experimental Arm 6-12-25 repetitions per set — The exercise regimens will employ a mixture of compound exercises utilizing both open and closed kinetic chain movements (CKC), focusing on exercises with the goal of increasing skeletal muscle mass and body composition. The regimen will incorporate 6, then 12, then 25 repetitions in sequence per set per muscle group with minimal amounts of rest between.
Primary outcomes
- Determine changes in muscle and fat mass during and after each exercise regimen (The exercise program will last for 8 weeks and continuously monitored by the PI and clinical team.)
Eligibility information
Inclusion Criteria:
Age 20-89 years
* Women with a biopsy proven diagnosis of ductal carcinoma in situ or invasive carcinoma of the breast
* Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy. Women undergoing active chemotherapy are not allowed on study. Immunotherapy or targeted agent usage is allowed.
Exclusion Criteria:
* Any current treatment with cytotoxic chemotherapy for breast cancer
* Inability to safely engage in group sessions of resistance training as deemed by study PI
* Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by PI to be unsafe to engage in resistance training
Study locations
- Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 United States
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.