Recruiting
Hyperbaric Oxygen Therapy for Optic Neuropathies
The purpose of the study is to evaluate the neuroprotective efficacy of hyperbaric oxygen for the treatment in patients with optic neuropathy.
ClinicalTrials.gov IDNCT06128720
PhaseNA
Enrollment60
SponsorStanford University
Age18 Years and older
SexALL
Conditions studied
Optic Neuropathy, Glaucoma
About this study
The purpose of the study is to evaluate the neuroprotective efficacy of hyperbaric oxygen for the treatment in patients with optic neuropathy.
Interventions
- Device: Hyperbaric Oxygen — Participant will undergo 60 minutes of Hyperbaric oxygen at 1.5ATA while breathing 100% oxygen
- Device: Sham Hyperbaric Oxygen — Participant will undergo 60 minutes of Sham Hyperbaric Oxygen at atmospheric pressure while breathing room air.
Primary outcomes
- Change in Visual Field- Mean Deviation (Baseline through 6 months)
- Change in Visual Field- Visual Field Index (Baseline through 6 months)
Eligibility information
Inclusion Criteria:
* Patients must meet all of the following criteria to join the study (all eligibility criteria must be met at the screening and baseline visits unless otherwise noted):
* Participant must be at least 18.
* Participant must has the ability to comply with the requirements of the study and complete the schedule of events (SOE).
* Participant's with clinical evidence of optic neuropathy.
* Participant must understand and sign the informed consent. If the participant's vision is impaired to the point where he/she cannot read the informed consent document, the document will be read to the participant in its entirety.
Exclusion Criteria:
* Participant is unable to comply with study procedures or follow-up visits.
* Participant has evidence of corneal opacification or lack of optical clarity.
* Participant is currently participating in or has within the last 3 months participated in any other clinical trial of a drug by ocular (if in the study eye) or systemic administration.
* Participant is pregnant or lactating.
* Participant has, in the opinion of the investigator, any physical or mental condition that would increase the risk of participation in the study or may interfere with the study procedures, evaluations and outcome assessments.
* Children and comatose patients.
* Participant abusing drugs or alcohol.
* Prior treatment with hyperbaric oxygen within the last 6 months.
* Participant with claustrophobia or that cannot decompress properly.
Study locations
- Byers Eye Institute, Palo Alto, California 94303 United States
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-11-06.