Neuromodulation in Patients With Neuropathic Pain and Depression.
High-frequency repetitive transcranial magnetic stimulation of the primary motor cortex has shown its effect on refractory neuropathic pain, and rTMS of the dorsolateral prefrontal cortex is commonly used for treatment-resistant depression. The treatment for patients suffering from neuropathic pain and depression, concomitantly, still needs to be studied, as there are some specificities in both symptoms and brain functional MRI.
Conditions studied
Neuropathic Pain, Depression
About this study
High-frequency repetitive transcranial magnetic stimulation of the primary motor cortex has shown its effect on refractory neuropathic pain, and rTMS of the dorsolateral prefrontal cortex is commonly used for treatment-resistant depression. The treatment for patients suffering from neuropathic pain and depression, concomitantly, still needs to be studied, as there are some specificities in both symptoms and brain functional MRI.
Interventions
- Device: Repetitive transcranial magnetic stimulation (rTMS) - M1/DLPFC — Repetitive transcranial magnetic stimulation (rTMS) is a treatment technique involving the induction of an electrical current on the surface of the cortex by applying a magnetic field to the scalp. This field is generated using a stimulation loop controlled by a robotic arm linked to a neuronavigation system. rTMS of M1 then rTMS of DLPFC.
- Device: Repetitive transcranial magnetic stimulation (rTMS) - DLPFC/M1 — Repetitive transcranial magnetic stimulation (rTMS) is a treatment technique involving the induction of an electrical current on the surface of the cortex by applying a magnetic field to the scalp. This field is generated using a stimulation loop controlled by a robotic arm linked to a neuronavigation system. rTMS of DLPFC then rTMS of M1.
Primary outcomes
- Comparison of pain relief rates between the two stimulation targets (M1 and DLPFC) (2 weeks after the last rTMS session for each arm)
Eligibility information
Study locations
- CHU de Saint-Etienne, Saint-Etienne, 42055 France
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-15.