Recruiting
A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)
The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
ClinicalTrials.gov IDNCT06150560
PhasePHASE3
Enrollment120
SponsorMayo Clinic
Age18 Years and older
SexALL
Conditions studied
Coarctation of Aorta, High Blood Pressure
About this study
The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
Interventions
- Drug: Losartan — 50mg administered orally once daily for 52 weeks.
- Drug: Amlodipine — 5mg Amlodipine administered orally once daily for 52 weeks.
- Drug: Placebo — Oral capsules that contain no active drug ingredients administered orally once daily for 52 weeks.
Primary outcomes
- Change in Left Ventricular (LV) Fibrosis (Baseline; Week 52)
Eligibility information
Inclusion Criteria:
* B/S1 hypertension
* SBP 100-139 average based on 3 office measurements.
* Age 18 or Older
* Previous COA Repair
Exclusion Criteria:
* Currently on beta blocker (BB) therapy
* Pregnancy/lactating
* eGFR\<30
* Hyperkalemia (serum potassium \>5.5mmol/L)
* Severe Aortic or Mitral valve stenosis or regurgitation
* Epicardial CAD diagnosis
* Received antihypertensive medications within the past year
Study locations
- Mayo Clinic in Rochester, Rochester, Minnesota 55905 United States
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-07.